Novoprotein 2024年10月28日

Novoprotein深耕重組蛋白及試劑產業十餘年，致力於為廣大科研、醫藥研究人員提供穩定、優質的產品及服務，每年都有大量的科研成果在Novoprotein產品的支持下成功發表於各種國際頂刊。

2024年8月，多達99篇文章使用Novoprotein基礎科研試劑、細胞激素、標靶蛋白等產品，其中IF最高為27.7，10分以上文獻有26篇！其中，明星產品All-in-one逆轉錄試劑盒（目錄號：E047.）、PCR試劑盒（目錄號：E005）助力多篇高分文章發表！

助力表觀遺傳學研究
武漢大學病毒學國家重點實驗室陳宇老師團隊在Science Advances發表題為“Epitranscriptomic m5C methylation of SARS-CoV-2 RNA regulates viral replication and the virulence of progeny viruses in the new infection”的研究論文。
研究者使用Novoprotein All-in-one逆轉錄試劑盒（目錄號：E047），對5-甲基胞嘧啶（m5C）的修飾進行了探究，揭示了NSUN2基因在介導的SARS-CoV- 2 複製過程中扮演的關鍵角色。

圖1 NSUN2介導的m5C修飾調節SARS-CoV-2 複製和感染能力

Epitranscriptomic m⁵C methylation of SARS-CoV-2 RNA regulates viral replication and the virulence of progeny viruses in the new infection
期刊 Science Advances. Impact Factor 11.7
引用Novoprotein產品 E047
https://www.science.org/doi/full/10.1126/sciadv.adn9519

助力基因編輯技術
中國科學院大連化學物理研究所葉明亮老師團隊在Nature Communications發表題為「Metabolic labeling based methylome profiling enables functional dissection of histidine methylation in C3H1 zinc fingers」的研究論文。
研究者使用Novoprotein的PCR試劑盒（目錄編號：E005），對基因編輯產物進行精準地研究和分析，提出了一種用於全局甲基化組的特異性代謝標記方法，為蛋白質甲基化如何調節細胞過程提供了新的理解。


Metabolic labeling based methylome profiling enables functional dissection of histidine methylation in C3H1 zinc fingers
期刊 Nature Communications. Impact Factor 14.7
引用Novoprotein產品 E005
https://www.nature.com/articles/s41467-024-51979-2


Targeting p97–Npl4 interaction inhibits tumor T_reg cell development to enhance tumor immunity
期刊 Nature Immunology. Impact Factor 27.7
引用Novoprotein產品CK24. CG39.CG09.CG50
https://www.nature.com/articles/s41590-024-01912-y 


Light-activated polymeric crosslinked nanocarriers as a checkpoint blockade immunoregulatory platform for synergistic tumor therapy
期刊 Materials Today. Impact Factor 27.7
引用Novoprotein產品CK15. CK02
https://www.sciencedirect.com/science/article/abs/pii/S1369702124001536


Generation of human region-specific brain organoids with medullary spinal trigeminal nuclei
期刊 Cell Stem Cell. Impact Factor 19.8
引用Novoprotein產品C029. C060. C076
https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(24)00290-X


Controlling Alveolar Bone Loss by Hydrogel-Based Mitigation of Oral Dysbiosis and Bacteria-Triggered Proinflammatory Immune Response
期刊 Advanced Functional Materials. Impact Factor 18.5
引用Novoprotein產品CG39. CF09
https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.202409121 


CRISPR-Cas target recognition for sensing viral and cancer biomarkers
期刊 Nucleic Acids Research. Impact Factor 16.6
引用Novoprotein產品E365
https://academic.oup.com/nar/article/52/17/10040/7742385


Low-Dose Mildronate-Derived Lipidoids for Efficient mRNA Vaccine Delivery with Minimal Inflammation Side Effects
期刊 ACS Nano. Impact Factor 15.8
引用Novoprotein產品MR009.
https://pubs.acs.org/doi/10.1021/acsnano.4c06160 


PPARα affects hepatic lipid homeostasis by perturbing necroptosis signals in the intestinal epithelium
期刊 Acta Pharmaceutica Sinica B. Impact Factor 14.7
引用Novoprotein產品E168.
https://www.sciencedirect.com/science/article/pii/S2211383524003411


Gut microbiota-derived indole-3-acetic acid suppresses high myopia progression by promoting type I collagen synthesis
期刊Cell Discovery. Impact Factor 13
引用Novoprotein產品N259-YH01.
https://www.nature.com/articles/s41421-024-00709-5